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Researchers from Columbia University used MRI-based neuÂroimagÂing to study the impact of the Mediterranean diet on brain strucÂture in elderly subÂjects, findÂing that higher adherÂence to the diet was assoÂciÂated with larger brain volÂumes and corÂtiÂcal thickÂness. The study sugÂgests that conÂsumÂing more fish and less meat as part of the Mediterranean diet may help delay brain shrinkÂage assoÂciÂated with aging and preÂvent cogÂniÂtive decline.
While sevÂeral well-known studÂies have found that the Mediterranean diet lowÂers the risk of Alzheimer’s disÂease, other studÂies have failed to conÂfirm these findÂings. According to authors of a recent paper pubÂlished in the jourÂnal Neurology, difÂferÂences in the methÂods used and subÂjecÂtivÂity of clinÂiÂcal diagÂnoÂsis may account for some of the inconÂsisÂtent results.
To remove bias in clinÂiÂcal assessÂment, researchers from Columbia University used MRI-based neuÂroimagÂing to examÂine the role of the Mediterranean diet on strucÂtural changes that occur due to aging.
Higher fish and lower meat intake might be the 2 key food eleÂments that conÂtribute to the benÂeÂfits of the Mediterranean diet on brain strucÂture.
The invesÂtiÂgaÂtors used speÂcific MRI bioÂmarkÂers to assess strucÂtural changes, brain volÂume and corÂtiÂcal thickÂness of 674 elderly, demenÂtia-free subÂjects, whose averÂage age was 80 years.
The mulÂtiÂethÂnic subÂjects livÂing in northÂern Manhattan comÂpleted food freÂquency quesÂtionÂnaires which were used to calÂcuÂlate Mediterranean Diet Scores and deterÂmine adherÂence to the Mediterranean diet.
Results of MRI markÂers showed that subÂjects who had a higher Mediterranean diet score and higher adherÂence to the Mediterranean diet had larger total brain volÂume, total gray matÂter volÂume and total white matÂter volÂume comÂpared to those who had a lower adherÂence to the Mediterranean diet.
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The benÂeÂfit of higher fish intake and lower meat intake was also observed: Subjects who conÂsumed more fish and less meat had larger total gray matÂter volÂume. Similarly, higher fish conÂsumpÂtion was assoÂciÂated with larger mean corÂtiÂcal thickÂness, while those who conÂsumed smaller amounts of meat had larger total brain volÂume.
The researchers also found that, when adjusted for age, those who conÂsumed alcoÂhol in modÂerÂaÂtion in addiÂtion to conÂsumÂing more fish and less meat had larger brain volÂumes.
The results of this study imply that brain shrinkÂage, a natÂural physÂiÂoÂlogÂiÂcal change that occurs with aging, may be delayed by conÂsumÂing the Mediterranean diet, a diet rich in fish, vegÂetaÂbles, legumes, fruits, cereÂals, nuts and monounÂsatÂuÂrated fats such as those found in olive oil.
The authors of the study report that weekly intake of 3 to 5 ounces of fish and reducÂing meat intake to less than 100 gram daily could proÂtect against brain shrinkÂage equivÂaÂlent to 3 to 4 years of aging.
While the exact sciÂence behind these findÂings is not yet known, the study results show that the benÂeÂfits of conÂsumÂing the Mediterranean diet extend to delayÂing brain shrinkÂage assoÂciÂated with aging and may preÂvent cogÂniÂtive decline.